Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Fig. 1

CpG ODN prolonged survival in CpG ODN-treated immunocompetent wild-type and neutropenic wild-type mice. (a) Treatment protocol. A single intraperitoneal (ip) CpG ODN was administered on day − 3, i.e., 3 days prior to infection. Mice were infected intracerebrally (ic) on day 0. Mice rendered neutropenic received anti-Ly-6G monoclonal antibodies ip from day − 4 until day 2. Kaplan-Meier curves in immunocompetent (b) and neutropenic (d) wild-type mice showed a prolonged survival (log-rank test, P < 0.05) and a tendency towards decreased mortality in CpG ODN-treated mice. (c) CpG ODN had no effect in Toll-like receptor 9-deficient mice (TLR9−/−)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094