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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Fig. 3

CpG ODN pre-treatment reduced pneumococcal concentrations in the brain, blood, and spleen in neutropenic wild-type animals. Bacterial loads were quantified in cerebellum and spleen homogenates as well as in the blood of neutropenic mice from bacteriological studies with end point at (a) 24 h and (b) 36 h after infection. (c) Bacterial concentrations were also assessed in neutropenic mice which succumbed to the infection during survival studies. Data are shown as medians, and each symbol represents an individual mouse. The detection limit was 102 colony-forming units (CFU)/ml in all homogenate samples, and 102 or 103 CFU/mL in the blood. The Mann-Whitney U test was used to compare the bacterial concentrations in the CpG ODN- and buffer-treated groups

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