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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Fig. 4

Microglial quantification and activation. (a) Microglial cells visualized by Iba-1 immunostaining were quantified, and their activation status was assessed in animals sacrificed 24 h after infection. Scale bar, 100 μm. Numbers of Iba-1-stained microglia in (b) immunocompetent and (c) neutropenic wild-type mice, and in (d) TLR9-deficient animals. (e) Microglial activation was stronger in infected wild-type immunocompetent than in infected granulocyte-depleted wild-type mice (P = 0.001). (f-i) Typical examples of the activation status of individual microglial cells: score 1—cells with relatively big somata but fine ramifications (f); score 2—hypertrophic cells with thicker branches (g); score 3—bushy cells (h); score 4—amoeboid microglia without processes (i)

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