Fig. 5

CpG ODN effects on IL-12/IL-23p40 and MIP-1α concentrations in spleen homogenates of infected immunocompetent wild-type mice. (a-d) In a set of bacteriological studies, spleen tissue from CpG ODN- and buffer-treated wild-type animals was obtained 5 h before (i.e., at this time point animals were uninfected) and 24 h after intracerebral challenge with S. pneumoniae D39. (e, f) In another set of experiments, spleens were obtained from wild-type animals which succumbed to the infection during survival studies. Data are shown as medians, and each symbol represents one immunocompetent mouse. CpG ODN- and buffer-treated groups were compared by Mann-Whitney U test. All concentrations measured were above the levels of detection