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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Oligodeoxynucleotides containing unmethylated cytosine-guanine motifs are effective immunostimulants against pneumococcal meningitis in the immunocompetent and neutropenic host

Fig. 7

Serum levels of IL-12/IL-23p40 in uninfected and infected immunocompetent wild-type animals. (a, b, d and e) In bacteriological studies, serum samples from the same CpG ODN- and buffer-treated wild-type animals were obtained 5 h before and 24 h after intracerebral challenge with S. pneumoniae D39. (c and f) In another set of experiments, serum samples were obtained in wild-type animals 36 h after pneumococcal injection. Data are shown as medians, and each symbol represents an individual mouse. Data between CpG ODN- and buffer-treated groups were compared by Mann-Whitney U test. All concentrations measured were above the levels of detection. In c, e, and f, IL12/IL-23p40 inversely correlated with bacterial concentrations in the blood suggesting that IL12/IL-23p40 release was mainly caused by CpG ODN and less by the presence of bacteria

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Journal of Neuroinflammation

ISSN: 1742-2094