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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Metabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease

Fig. 9

Schematic graph for the role of mGluR5 in mediating α-syn-induced microglia inflammation to protect from neurotoxicity. Activation of mGluR5 with CHPG dissociates its interaction with α-syn, leading to the increased expression of mGluR5 via reduced lysosome-dependent degradation, further downregulating the related inflammatory signaling, and subsequently inhibiting microglia inflammation to prevent neurotoxicity. In contrast, blockade of mGluR5 with MTEP enhanced the α-syn-induced inflammation by aggravated inflammatory signaling, leading to an increase of the vulnerability of neurons to degeneration

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Journal of Neuroinflammation

ISSN: 1742-2094