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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis

Fig. 2

Localization of leukocytes within the eyes after treating with GW559090. There was an increase in leukocytes around the optic nerve (× 200; a), within the anterior chamber (× 200; b), retinal layers, and within the vitreous cavity (× 400; c) in vehicle-treated control (Veh). In GW10-treated eyes, decreased levels of cells were detected around the optic nerve (× 200; d), in the anterior chamber (× 200; e), and within the vitreous (× 400; f). Mean ± SEM scores were calculated for cell numbers infiltrating the vitreous (g), anterior chamber (h), and inner retina (i) in all groups. j Cellular infiltration score. n = 5 in each treatment group. *P < 0.05; **P < 0.01, using a two-tailed, unpaired Student’s t test

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