Fig. 1

Cardiomyocyte-restricted expression of misfolded CryAB^R120G protein exacerbated I/R-induced brain injury and cognitive and motor deficits. a Diagram of the experimental design, the numbers in the parentheses indicating the number of animals used. b TTC staining mouse brains after 24 h of reperfusion. c Quantitative analysis of (b). d Representative images of Nissl staining results in the peri-infarct cortical area after 7 days of reperfusion. Scale bar, 100 μm. e Quantitative analysis of (d) from 4 mice with 12–15 sections/animal. f Survival rate of mice after MCAO. g Functional recovery of mice after MCAO. h String agility test results after 14 days of reperfusion. i Rotarod test results after 14 days of reperfusion. j Object recognition test results after 14 days of reperfusion. k Y-maze test results after 14 days of reperfusion. l Radial arm water maze (RAWM) results after 14 days of reperfusion. Numerical data are shown as mean ± SEM; n = 9 (the beginning numbers for the survival test was 14 for Ntg mice and 29 for CryAB ^R120G mice). *p < 0.05, **p < 0.01, $p < 0.001, #p < 0.0001