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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Microglia as target for anti-inflammatory approaches to prevent secondary brain injury after subarachnoid hemorrhage (SAH)

Fig. 1

MRI-scans and experimental protocols after SAH. a T2*-weighted sequence (24 h), Bregma + 0.5 mm, arrow pointing at SAH, T2-weighted sequence (24 h), ruling out SAH-associated complications like intraparenchymal bleeding or ischemia. b Illustrative image of time-of-flight (TOF)-MR-angiography (maximum intensity projection) performed before (left), right after (middle), and in the course of SAH (right). Regular cerebrovascular perfusion was seen before the bleeding. Directly after the bleeding, cerebrovascular structures seemed impaired (arrows), possibly due to a rise of the intracranial pressure and a breakdown of the cerebral perfusion. Cerebrovascular perfusion was restored later (arrows, measurement 3 days after the bleeding). c Timeline of experimental protocol for inflammatory preconditioning and pharmacological deactivation using PLX3397 are displayed, indicating the timepoints of interventions and diagnostics as well as treatment duration. d Illustration of the 3 representative levels for immunofluorescence analysis (right) and distribution of the representative HPFs for microglia and neuronal cell count (left)

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