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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Fig. 7

The effect of TGR5 knockdown on the levels of Pellino3, cleaved caspase-8, and NLRP3, and on brain damage after middle cerebral artery occlusion (MCAO). The band of Western blot analysis (a) and the relative density (b) of TGR5, Pellino3, cleaved caspase-8, and NLRP3. c Dosing with TGR5 siRNA increases infarct volume and worsens neurobehavioral deficits. n = 6 per group. *P < 0.05 vs. Sham, #P < 0.05 vs. MCAO + Scr-siRNA. Bars represent mean ± SD. Scr-siRNA scrambled-siRNA

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