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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Fig. 8

TGR5 or Pellino3 knockdown abolishes the anti-inflammatory effects of INT777 after middle cerebral artery occlusion (MCAO). a, b Representative Western blot bands and quantitative analyses of the protein levels of TGR5, Pellino3, cleaved caspase-8, NLRP3, cleaved caspase-1, and IL-1β. c Quantified infarct ratio and neurological scores, n = 6 per group. *P < 0.05 vs. Sham, #P < 0.05 vs. MCAO + vehicle, @P < 0.05 vs. MCAO + INT777 + Scr-siRNA group. Scr siRNA scrambled-siRNA

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