Fig. 5

Hippocampal synaptic plasticity changes on day 7 after anesthesia/surgery. a A hippocampal profile image of Golgi staining and camera tracings of hippocampal CA1 neurons. b Sample images of Golgi-Cox staining of CA1 neurons for spine counting. c Representative dendritic spine density of hippocampal CA1 neurons. d Quantitation of dendritic intersections (n = 18). e Quantitation of the total dendritic length (n = 18). f Quantitation of the dendritic spine density (n = 18). g Sample images showing the location of the MED64 probe in the CA1 region. h LTP recording in the hippocampal CA1 region. Arrows indicate the time point of TBS application. I. Averaged fEPSP slope during the last 20 min. The data are presented as the means ± standard error of the mean for each group (n = 6). *p < 0.05, **p < 0.01 compared with the control group. Scale bar = 10 μm