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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

Fig. 9

SIRT3 overexpression alleviated anesthesia/surgery-induced hippocampus-dependent cognitive dysfunction in aged mice. The total distance traveled in the OFT among the 4 groups at 1 day before and 1, 3, and 7 days after anesthesia/surgery (ad). The percent freezing time was assessed during the training session on 1 day preoperatively (e) as well as in the context test (fh) and tone test (ik) at postoperative days 1, 3, and 7. The data are presented as the means ± standard error of the mean for each group (n = 10). *p < 0.05, **p < 0.01 compared with the C + VEH group, #p < 0.05 compared with the A/S + VEH group

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