Fig. 6

Exifone treatment reversed the neuroprotective effect of fluoxetine. a Drug treatment schedule, b FST, c OFT, d BV-2 cell drug treatment schedule, e BV-2 cell viability assay, f HDAC1 activity in exifone, LPS, and fluoxetine-treated BV-2 cells, g TNF-α level in cell lysate, h TNF-α in cell supernatant, i IL-6 level in cell lysate, j IL-6 in cell supernatant, k IL-1β level in exifone, LPS, and fluoxetine-treated BV-2 cell lysates. Data were expressed as ± SEM, one-way ANOVA followed by post hoc analysis. p = < 0.05 were considered significant. *p < 0.05, **p < 0.01), ***p < 0.001, ****p < 0.0001