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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury

Fig. 5

PF543 prevents M1 microglia-induced neuronal apoptosis. a TUNEL assay was performed in neurons cocultured with microglia (scale bar: 100 μm). The neuronal apoptosis induced by M1 microglia was significantly attenuated in cells cocultured with PF543 pretreated microglia. b Representative Western blots and quantitative data for Bcl-2, Bax, cleaved caspase 3, and GAPDH expression in each group of neurons. n = 3 independent experiments. *P < 0.05 and **P < 0.01

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