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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

Fig. 4

IL-1 signaling mediates cognitive impairment and abnormal expression of mitochondrial fission and fusion proteins caused by AβOs in mice. a Experimental design for behavior experiments with Il1r1−/− mice i.c.v. injected with vehicle or 100 pmol AβOs. b, c Exploration times of WT or Il1r1−/− mice 24 h or 7 days after a single i.c.v. injection with vehicle or 100 pmol AβOs in the NOR task. Data are expressed as means ± SEM (n = 11–12 animals per experimental group). Asterisks denote a statistically significant (p < 0.05) difference from 50% (reference value). One-sample Student’s t test. d 9 days after i.c.v. injection of AβOs (100 pmol), the same animals were trained in the contextual fear conditioning task. The percentage of freezing behavior in this task is shown. Data are expressed as means ± SEM (n = 6–7 animals per experimental group. **p < 0.01, ***p < 0.001 compared to vehicle or AβOs, two-way ANOVA followed by Holm-Šidak post hoc test. e MFN-1, f MFN-2, g OPA-1, and h Drp1 mRNA levels in the hippocampi of mice 12 days after i.c.v. injection of AβOs (100 pmol). *p < 0.05 compared with vehicle or AβOs (n = 6–7 animals per experimental group). Two-way ANOVA followed by Holm-Šidak post hoc test. i IL-1β mRNA levels in the hippocampi of mice 12 days after i.c.v. injection of AβOs (100 pmol). Following AβO injection, animals were treated for 7 days with saline or mdivi-1 (40 mg/kg; i.p.; n = 9–10 animals/group). *p < 0.05 compared with vehicle or AβOs, two-way ANOVA followed by Holm-Šidak post hoc test

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