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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

Fig. 3

Endogenous tPA stimulates CD4+ T cell proliferation and activation. tPA-/- and WT splenocytes were activated with anti-CD3 and anti-CD28 antibodies (both 1 μg/mL) and treated in the indicated conditions for 4 days. a Representative flow cytometry histograms for proliferation (CFSE) and activation (CD25+) of T cells. Corresponding quantification of proliferation index for b CD4+and c CD8+ T cells. Percentage of increase of CD25 for d CD4+ and e CD8+ T cells. Results are expressed as mean + SEM (N = 5). *P < 0.05

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