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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses

Fig. 6

tPA polarizes splenic APCs from EAE mice towards a pro-inflammatory phenotype. Splenocytes extracted from EAE mice at the peak of the clinical course were treated in the indicated conditions. a, b Percentage of a CD11c+MHC-II+-DCs and b F4/80+ MHC-II+-Mɸ in each APC subpopulation. c, d MFI of MHC-II in APCs, e–h Percentage of e, f MHC-II+ CD80+ CD86+ immunogenic and g, h and MHC-II+ CD80- CD86- tolerogenic APCs in the presence of different tPA concentrations. In all cases, tPA at the concentrations of 0.2 and 20 μg/mL showed no differences. Results are expressed as mean + SEM (N = 5), *P < 0.05

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