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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway

Fig. 3

MiR-409-3p promoted murine BV-2 microglial migration, activation and neuroinflammation. a Murine BV-2 cells were transfected with miR-409-3p mimics NC or miR-409-3p mimics. The miR-409-3p levels were detected by qRT-PCR. b The migratory ability of murine BV-2 cells was measured by Transwell assay. Scale bar 10 μm. c Immunofluorescence staining for Iba1 and CD68 was used to evaluate murine BV-2 microglial activation. Scale bar 50 μm. dg CD86, IL-1β and inflammatory cytokines (IL-6, TNF-α) were detected via qRT-PCR and ELISA. Cell culture experiments were performed in triplicates. *P < 0.05; **P < 0.01; ***P < 0.001

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