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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway

Fig. 6

Exosomes secreted by mast cells rich in miR-409-3p promoted microglial activation. a Iba1 and CD68 was used to detect microglial activation. Immunofluorescence assays were used to measure the Iba1 and CD68 levels in the hippocampus in the PBS group, P815-miR-409-3p mimics NC-exosomes group (mimics NC exo) and P815-miR-409-3p mimics-exosomes group (mimics exo). Scale bar 50 μm. b Western blotting was used to detect Nr4a2 and NF-κB/p65 protein expression. n = 5 C57BL/6 mice per group

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