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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice

Fig. 1

Intestinal injury of murine NEC involves NLRP3 inflammasome activation. a Representative gross images of the intestine from the control and NEC group at P11. Blue arrows indicate pneumatosis intestinalis, and red arrow indicates intestine hyperemia. b Representative H&E staining of intestinal sections from control and NEC group. c Western blot analysis of NLRP3, cleaved caspase-1, pro IL-1β (31kD), and mature IL-1β (17kD) expression in intestinal homogenates. β-actin was regarded as a loading control, and the relative intensity of the bands was quantified (n=2–3 mice per group). d Representative IL-1β and NLRP3 immunohistochemical staining of intestinal tissues from control and NEC group. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01 vs. control group

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