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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Blockage of NLRP3 inflammasome activation ameliorates acute inflammatory injury and long-term cognitive impairment induced by necrotizing enterocolitis in mice

Fig. 5

MCC950 administration in early life induces long-term protection from NEC-associated cognitive impairments in mice. a Schematic diagram of the experimental design. b Average swim speed at the first day and escape latency during the MWM spatial training phase. c Representative swim paths and crossing-platform times in the MWM probe test (n = 10–11 mice per group). d Western blot analysis of MBP and NeuN levels in brain homogenates. The relative intensity of the bands was quantified (n = 3 mice per group). Values are presented as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. NEC group

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