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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice

Fig. 6

Inhibition of CCR4 and AKT reversed the effects of rCCL17 on neurological functions and inflammatory/apoptotic proteins expression. a Modified Garcia test, corner turn, test and forelimb placement test of each group at 72 h after ICH. b, c Representative western blot bands and quantitative analyses of CCR4, PI3K, phosphorylated AKT (p-AKT), AKT, Foxo1, TNF-α, IL-1β, Bax, and Bcl-2 expression in the ipsilateral hemisphere at 72 h after ICH. *p<0.05 vs sham, @p<0.05 vs ICH + vehicle, #p<0.05 vs ICH + rCCL17, $p<0.05 vs ICH + rCCL17+ DMSO, mean ± SD, one-way ANOVA, Tukey’s test, n=6/group

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Journal of Neuroinflammation

ISSN: 1742-2094