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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

Fig. 1

Proposed mechanism of age and immunological contributions to typical CIDP pathology. In CIDP, there is a decline in regulatory T cells which are opposite to the age-related increase in these cells. In combination with a decline in naïve T cells with age, this may contribute to the CIDP-related increase in Th17 cells, thus creating an imbalance in Tregs and Th17 cells. Due to dysregulation of the immune system, this may allow for further pathological contributions of the infiltrating natural killer T cells and distorted CD8+ T cell repertoire seen in CIDP. Also, with age, there is an increase in macrophages within the peripheral nerve and in combination with an increase in macrophages due to CIDP, and this could contribute to an age-related increase in disease severity. Orange arrows = age-related contribution; green arrows = disease-related contribution; combination of green and orange arrows = cumulative contribution of age and disease

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