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Fig. 11 | Journal of Neuroinflammation

Fig. 11

From: A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury

Fig. 11

Microgliosis and astrogliosis at 4 days post-LPS (i.e., 8 days post-TBI) revealed by increased immunoreactivity for Iba1 and GFAP, in the cortex (a) and hippocampus (d). Quantification (ipsilateral measurements normalized to the contralateral side, expressed as fold change of % area) found that Iba1 reactivity was increased in TBI compared to sham mice in the lesioned cortex (b) as well as the hippocampus (e). GFAP immunoreactivity in the cortex was non-significant (c), however, was significantly increased in hippocampus (f) and revealed TBI effects in the hippocampus specifically. No effects of LPS alone were noted. Two-way ANOVA, effect of injury *p ≤ 0.05; n = 5–6/group. Scale bar = 50 μm (a) and scale bar = 100 μm (d)

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