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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: The psychoactive drug of abuse mephedrone differentially disrupts blood-brain barrier properties

Fig. 3

Mephedrone affects tight junction protein expression and localization in hBMVEC. a Representative immunoblots of occludin, claudin-1, and claudin-5 from cytosolic and membrane fractions of endothelial cells treated with 10 μM mephedrone for 24 h. b The plots represent densitometry analysis of the target band intensity normalized to the GAPDH (cytosolic fraction) or NaK-ATPase (membrane fraction) band intensities and relative to the untreated control. The results are shown as the percentage of the mean value ± SEM. Experiments were independently performed three times. Within each individual experimental set, primary cells from four different donors were used (n = 12)

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