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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease

Fig. 5

Ablation of astrocytes alters synaptic density in OBCSs. (a) Quantification and (b) representative images of dendritic spine density and size in hippocampus (CA1 and CA3 areas) of organotypic cultures of thy-1-GFP transgenic mice crossed with 5XFAD mice or WTs incubated with 0.6-μM synthetic Aβ and treated for 24 h with L-AAA or vehicle (n=12–18). Scale bar= 1 µm values shown in graphs represent the mean value ± SEM. Statistical analysis included one-way or two-way ANOVA with Tukey’s or Holm-Sidaks multiple-comparison post-hoc test, *P<0.05; **P<0.01; ***P<0.001

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