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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

Fig. 2

Pexidartinib reduces macrophage numbers in AxD mice. Immunofluorescence was performed for IBA1 and the number of IBA1+ cells counted. Data are presented as the average number of cells per field of view (FOV) for the olfactory bulb glomerular layer (a) and the dentate gyrus of the hippocampus (b). RT-qPCR for Aif1 (Iba1) in the olfactory bulb (c) and hippocampus (d). Statistical analyses: One-way analysis of variance (ANOVA) with Bonferroni’s post-test for the indicated comparisons. n.s., non-significant (p>0.05), *p<0.05, ***p<0.001. N =5-8 per group for IBA1 counts. N = 5-6 per group for Aif1 RT-qPCR data

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Journal of Neuroinflammation

ISSN: 1742-2094