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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

Fig. 4

Pexidartinib treatment of AxD mice results in elevation of GFAP levels. RT-qPCR for Gfap was performed on mRNA isolated from olfactory bulb (a) and hippocampus (b). GFAP protein levels in the olfactory bulb (c) and hippocampus (d) were measured by ELISA. Rosenthal fiber accumulation was analyzed in the olfactory bulb glomerular layer (e) and along the hippocampal fissure (f), median shown in graph and horizontal line indicates group median. Statistical analysis: One-way ANOVA with Bonferroni’s post-test for the indicated comparisons for RT-qPCR and ELISAs, Mann-Whitney test for Rosenthal fiber accumulation analyses, n.s., non-significant (p>0.05), *p<0.05, **p<0.01,***p<0.001. N = 5-6 per group for Gfap RT-qPCR and GFAP ELISA. N = 4-5 per group for Rosenthal fiber accumulation scoring

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