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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

Fig. 5

Pexidartinib has limited impact on expression levels of astrogliosis and stress response markers in AxD mice. RT-qPCR for Lcn2 for the olfactory bulb (a) and hippocampus (b), Cryab for the olfactory bulb (c) and hippocampus (d), Nfe2l2 (Nrf2) for the olfactory bulb (e) and hippocampus (f), and Nqo1 for the olfactory bulb (g) and hippocampus (h). Statistical analyses: One-way ANOVA with Bonferroni’s post-test for the indicated comparisons, n.s., non-significant (p>0.05), *p <0.05, **, p<0.01, ***p<0.001. N = 5-6 per group

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