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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes

Fig. 6

Pexidartinib has limited impact on expression of cytokines and chemokines in AxD mice. RT-qPCR for Il6 (a) and Il1b (b) was performed on mRNA isolated from olfactory bulb and hippocampus, but only olfactory bulb is shown because expression of these cytokines was not detected in the hippocampus. RT-qPCR for Cxcl1 for the olfactory bulb (c) and hippocampus (d), and Cxcl10 for the olfactory bulb (e) and hippocampus (f). Data displayed in this figure are presented as values normalized to Tbp and relative to AxD control as 1. Statistical analyses: unpaired two-sided t test, n.s., non-significant (p>0.05), *p <0.05. N = 5-6 per group

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