Fig. 1

Effect of FIRS and postnatal inflammation on survival and growth. Rat pups were exposed to prenatal i.a. LPS (L) or saline (S) (listed first) and then postnatal i.p. LPS or saline at P5 (listed second) to create 4 treatment groups. a The percentage of pups from each litter surviving at 7 days of life following fostering is depicted (n = 20–22 litters). There was significantly lower survival in both groups that received postnatal LPS (SL and LL); prenatal treatment did not change survival outcomes (*p < 0.05 vs SS and LS). b Weights of pups that received i.a. LPS (LS and LL) were decreased on postnatal (P) day 5 prior to postnatal i.p. LPS injection (*p < 0.05 vs SS and SL; n = 12–30). At P7, all groups that received LPS prenatally or postnatally had lower weights than the controls (^#p < 0.05 vs SS; n = 6–17). Data presented as mean ± SEM