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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals

Fig. 3

Mice with two copies of the X chromosome have higher expression of KDM6A and KDM5C in ischemic brains. a, b Kdm5c and Kdm6a mRNA levels were measured by RT-PCR in aged WT mice brains. c, d Kdm5c and Kdm6a mRNA levels in FCG mice brains. e, g Western blots of KDM5C and KDM6A protein levels in brain homogenates of FCG mice. Tubulin was used as a loading control. f, h Optical density of KDM5C or KDM6A bands normalized to the loading control. Data were averaged from 3 to 4 independent experiments. n=5–6 animals/group, *p < 0.05; **p < 0.01; ***p < 0.001

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