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Table 1 Phenotypes of global BACE1 KO vs. macrophage specific BACE1 KO mice

From: The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve

Global BACE1 KO Macrophage specific BACE1 KO
Hypomyelination at baseline [6, 34] Normal myelination [70]
Enhanced axonal regeneration [8] Not determined
Reduced remyelination [7] Not determined
Enhanced macrophage recruitment [8] No enhanced macrophage recruitment [70]