Fig. 1

TSPO ligand, Ro5-4864, attenuates brain atrophy and neuronal loss in TauTg mice. a Representative T2-weighted RARE coronal (left), sagittal (middle), and horizontal (right) images of 9-month-old nonTg and TauTg mouse brains. Brain regions of cerebral cortex (CTX), hippocampus (HIP), and cerebellum (CB) are labeled in the sagittal slice of nonTg mice. Orientations of slice are indicated as “a” (anterior), “p” (posterior), R (right), and L (left). b-d Hippocampal (b), cerebral cortical (c), and cerebellar (d) volumes at baseline (5 m) and completion (9 m) in nonTg (N = 12) and TauTg mice treated with either vehicle (N = 6) or Ro5 (N = 7). e Representative images of NeuN (red) and DAPI (blue) immunoreactivity in the CA1 region of 9-month old nonTg and TauTg mice treated with either vehicle or Ro5. f Quantification of NeuN-labeled CA1 width in the hippocampus of nonTg (N = 12) and TauTg mice treated with either vehicle (N = 6) or Ro5 (N = 7). Mixed ANOVA was used except in (f), where one-way ANOVA was used. Individual data points plotted for each group and the group mean indicated (black bar). ***p < 0.001, **p < 0.01, *p < 0.05