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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

Fig. 2

No benefit of TSPO ligand on tau depositions measured by in vivo 11C-PBB3-PET. a Representative orthogonal views of 11C-PBB3 uptake distribution in brains of nonTg and TauTg mice following treatment with either vehicle or Ro5. Images were generated by averaging dynamic scan data across 60 min after intravenous injection of 11C-PBB3 and were overlaid on individual MRI data. b, c Time activity curves of the ratio of cortical (b) and hippocampal (c) 11C-PBB3 mean ± SEM uptake relative to cerebellum (cb) in nonTg (N = 11) and TauTg mice following treatment with either vehicle (N = 6) or Ro5 (N = 7). d, e Average ratio 11C-PBB3 uptake (relative cerebellum, cb) in cortex (d) and hippocampus (e) of nonTg and TauTg mice at baseline (5 m) and following treatment with either vehicle or Ro5-4864 (9 m). Individual data points plotted for each group and the group mean indicated (black bar). f Quantification of AT8 immunoreactivity (IR) in the hippocampus (Hp) and cortex (cx) of TauTg mice treated with either Ro5 (N = 7) or vehicle (N = 6). Individual data points plotted for each group and the group mean indicated (black bar). g Representative images of AT8 immunoreactivity in the hippocampus of nonTg and TauTg mice treated with either vehicle or Ro5. h Representative western blots showing total tau (tau-12) and GAPDH in brains from TauTg mice treated with either vehicle or Ro5. i Quantification of total tau corrected against GAPDH in TauTg mice treated with either vehicle (N = 6) or Ro5 (N = 7). Mixed ANOVA was used except in (i), where unpaired parametric T test was used. **p < 0.01, *p < 0.05

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