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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy

Fig. 3

Inflammatory signals detected by in vivo PET with 18F-FEBMP in TSPO ligand treated TauTg mice. a Representative orthogonal views of 18F-FEBMP uptake distribution in brains of nonTg and TauTg mice following treatment with either vehicle or Ro5. Images were generated by averaging dynamic scan data across 90 min after intravenous injection of 18F-FEBMP and were overlaid on individual MRI data. b, c Time activity curves of the ratio of mean ± SEM hippocampal (b) and cortical (c) 18F-FEBMP uptake relative to cerebellum (cb) in nonTg (N = 11) and TauTg mice following treatment with either vehicle (N = 6) or Ro5 (N = 7). d, e Average ratio 18F-FEBMP uptake (relative cerebellum, cb) in hippocampus (d) and cortex (e) of nonTg and TauTg mice at baseline (5 months) and following treatment with either vehicle or Ro5-4864 (9 months). Individual data points plotted for each group and the group mean indicated (black bar). f, g Association between hippocampal TSPO-PET signals and measures of neurodegeneration including hippocampal MRI volume (f) and CA1 width (g) assessed at study completion. Mixed ANOVA was used except in (f, g), where Spearman’s correlation was used *p < 0.05. ***p < 0.0001

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