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Table 1 Overview of studies comparing the microglial numbers between males and females in diverse brain regions

From: Uncovering sex differences of rodent microglia

Species Age Brain region Main differences References
Rat P4 Cortex Males have more amoeboid microglia [55]
Rat P4 Hippocampus Males have more amoeboid microglia [55]
Rat P4 Amygdala Males have more amoeboid microglia [55]
Rat P30 Cortex Females have more activated microglia [55]
Rat P30 Hippocampus Females have more activated microglia [55]
Rat P30 Amygdala Females have more activated microglia [55]
Rat P60 Cortex Females have more activated microglia [55]
Rat P60 Hippocampus Females have more activated microglia [55]
Rat P60 Amygdala Females have more activated microglia [55]
Rat P2 Preoptic area Males have more amoeboid-shaped microglia [56]
Rat P3 Hippocampus Females have more phagocytic microglia [53]
Mice 13 weeks Hippocampus Males have more Iba1+ microglial cell density [52]
Mice 13 weeks Cortex Males have more Iba1+ microglial cell density [52]
Mice 13 weeks Amygdala Males have more Iba1+ microglial cell density [52]
Mice 3 weeks Hippocampus Males have more Iba1+ microglial cell density [52]
Mice 3 weeks Amygdala Females have more Iba1+ microglial cell density [52]
  1. Abbreviations: P2 postnatal day 2, Iba1 Ionized calcium binding adaptor molecule 1
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