Uncovering sex differences of rodent microglia

Table 1 Overview of studies comparing the microglial numbers between males and females in diverse brain regions

Species	Age	Brain region	Main differences	References
Rat	P4	Cortex	Males have more amoeboid microglia	[55]
Rat	P4	Hippocampus	Males have more amoeboid microglia	[55]
Rat	P4	Amygdala	Males have more amoeboid microglia	[55]
Rat	P30	Cortex	Females have more activated microglia	[55]
Rat	P30	Hippocampus	Females have more activated microglia	[55]
Rat	P30	Amygdala	Females have more activated microglia	[55]
Rat	P60	Cortex	Females have more activated microglia	[55]
Rat	P60	Hippocampus	Females have more activated microglia	[55]
Rat	P60	Amygdala	Females have more activated microglia	[55]
Rat	P2	Preoptic area	Males have more amoeboid-shaped microglia	[56]
Rat	P3	Hippocampus	Females have more phagocytic microglia	[53]
Mice	13 weeks	Hippocampus	Males have more Iba1+ microglial cell density	[52]
Mice	13 weeks	Cortex	Males have more Iba1+ microglial cell density	[52]
Mice	13 weeks	Amygdala	Males have more Iba1+ microglial cell density	[52]
Mice	3 weeks	Hippocampus	Males have more Iba1+ microglial cell density	[52]
Mice	3 weeks	Amygdala	Females have more Iba1+ microglial cell density	[52]

Abbreviations: P2 postnatal day 2, Iba1 Ionized calcium binding adaptor molecule 1

ISSN: 1742-2094