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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Fig. 2

Effect of CCR2 antagonism on pain-related behaviors of CFA-treated rats. Animals received an intraplantar injection of 100 μL CFA with 4 mg/mL of M. butyricum in the left hind paw. Rats were treated daily by i.t. administration of 45 μg/kg INCB3344 starting at day 8 post-CFA (arrows). Pain was assessed 1-h post-treatment using (a) an automated von Frey test on days 3, 8, 9, and 10 post-CFA, and (b) a dynamic weight-bearing apparatus only at day 10 post-CFA. * relates to baseline or sham compared to vehicle (DMSO 6%), # to vehicle versus INCB3344. Data shown correspond to mean ± SEM (n = 8 for each group). *, #P < 0.05, **P < 0.01, ***P < 0.001; two-way ANOVA followed by Bonferroni post-tests

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Journal of Neuroinflammation

ISSN: 1742-2094