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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Mechanistic insights into the role of the chemokine CCL2/CCR2 axis in dorsal root ganglia to peripheral inflammation and pain hypersensitivity

Fig. 3

Central blocking of CCR2 activation reduces peripheral inflammation induced by CFA. The ipsilateral hind paw volume was measured by plethysmometry before and 3, 8, 9, and 10 days after CFA injection. Starting on day 8, animals received a daily i.t. injection of either vehicle (DMSO 6%) or INCB3344 1 h prior to edema measurement. Black bars represent vehicle-treated CFA animals whereas gray bars correspond to INCB3344-treated CFA animals. * Relates to baseline versus vehicle comparisons, # to vehicle versus INCB3344. Data correspond to mean ± SEM (n = 8 for each group). *, #P < 0.05, ***P < 0.001; two-way ANOVA followed by Bonferroni post-tests

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