Fig. 7

Tight ligature of the ipsilateral sciatic nerve reduces peripheral edema. Eight days after intraplantar administration of CFA, anterograde transport toward the periphery was blocked by a tight constriction of the sciatic nerve. Animals received three daily injection of INCB3344 or vehicle starting on day 8 post-CFA, 12 h before sciatic surgery. Hind paw volume was measured 48 h after the sciatic ligature. Data shown corresponds to mean ± SEM (n = 6 for each group). ^### P < 0.001 when comparing sham animals with CFA untreated and non-ligatured rats. *P < 0.05 when compared to CFA untreated and non-ligatured animals (one-way analysis of variance followed by Bonferroni post-test, only comparing with the CFA alone group)