TY - JOUR AU - Oladiran, Oladayo AU - Shi, Xiang Qun AU - Yang, Mu AU - Fournier, Sylvie AU - Zhang, Ji PY - 2021 DA - 2021/03/22 TI - Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy JO - Journal of Neuroinflammation SP - 77 VL - 18 IS - 1 AB - While the etiology remains elusive, macrophages and T cells in peripheral nerves are considered as effector cells mediating autoimmune peripheral neuropathy (APN), such as Guillain-Barre syndrome. By recognizing both pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) signals, TLRs play a central role in the initiation of both innate and adaptive immune responses. In this study, we aimed to understand the involvement of TLR4 in the pathogenesis of APN and explore the potential of TLR4 as a drug target for therapeutic use. SN - 1742-2094 UR - https://doi.org/10.1186/s12974-021-02126-x DO - 10.1186/s12974-021-02126-x ID - Oladiran2021 ER -