Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy

Fig. 4

The effect of TLR4 signaling inhibition on macrophage and CD8+ T cells number and activation status in the nerve of L31 mice. In the prevention paradigm (ad), a quantitative analysis from flow cytometry showed a reduced number of macrophages (CD45+CD11b+F4/80+) in treated group at the end of the experiment. (b) The number of activated macrophages (MHCI+CD86+) were significantly reduced in treated group. c Frequency and absolute number of infiltrating CD8+ T cells were significantly diminished in treated group. In the reversal paradigm (df), d quantitative analysis from flow cytometry showed that TAK 242 favored the reduction of nerve macrophages (CD45+CD11b+F4/80+). e A quantitative analysis indicated a reduced number of activated macrophages (MHCI+CD86+). Majority of the reduced macrophages in treated group were those committed to antigen-presenting function (MHCI+CD86+). f A representative flow cytometry dot plot showed a reduced frequency and number of infiltrating CD8+ T cells in the sciatic nerve of treated mice. All quantitative analyses are shown as number of cells per a segment of 2-cm-long sciatic nerve. n = 6/group; *p < 0.05; **p < 0.01; ***p < 0.001

Back to article page
\