Fig. 5From: Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathyThe effect of TLR4 signaling inhibition on cytokine expression in L31 mice. In the prevention paradigm (a–e), real-time quantitative PCR showed a significantly reduced expression of pro-inflammatory molecules a IFN-γ, b TNF-α, c IL-6, and d IL-1β, in the TAk 242-treated group. e The mRNA expression of the anti-inflammatory molecule, IL-10 was significantly enhanced in the treated group. In the reversal paradigm (f–j), the mRNA expression levels of f IFN-γ, g TNF-α, h IL-6, and i IL-1β, in the peripheral nerve were significantly reduced by TAK 242 treatment. j The mRNA level of IL-10 was unchanged across both groups in the reversal paradigm. n = 6/group; *p < 0.05; **p < 0.01; ***p < 0.001Back to article page