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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage

Fig. 2

Microgliosis in CX3CR1CreER/+:R26iDTR/+ transgenic mice 3 days after ischemic stroke. (a) Timeline of drug administration and tissue processing 3 days post stroke. (b) Distribution of microglia at the lesion site in vehicle-treated mice and microglia-depleted mice 3 days post stroke. Iba-1 was used to highlight microglia in CX3CR1CreER/+:R26iDTR/+ mice. Microglial accumulation zones were delineated by the dashed lines (scale bar = 200 μm). (c) Density of microglia in the accumulation zone with and without microglia depletion. (d) Width of the accumulation zone of reactive microglia with and without microglial depletion (n ≥ 3, **p < 0.01)

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