Fig. 3

CRHR1 antagonist CP154526 ameliorates spatial learning and memory deficits in DEX offspring. DEX offspring of 2 days old were subcutaneously administered with CP154526 (10mg/kg/day, 30mg/kg/day) for 7 days. Morris water maze test was performed on these rats in adulthood. a, b The escape latencies of CP154526 treated female (a) and male (b) DEX offspring in the 4-day platform acquisition training. c, the time that spent in the correct platform quadrant in the probe trial after training. d, the swimming speed of the rats. Data are presented as mean ± SEM (n=12 in each group). #P<0.05, ##P<0.01 vs DEX. CTL: control, CP: CP154526