Fig. 4

Antalarmin treatment improves spatial learning and memory in DEX offspring. DEX offspring of 2 days old were subcutaneously administered with antalarmin (10mg/kg/day, 30mg/kg/day) for 7 days as described in the “Materials and methods” section. Morris water maze test was performed on these rats in adulthood. a, b The escape latencies of female (a) and male (b) DEX offspring in the 4-day platform acquisition training. c, the time that spent in the correct platform quadrant in the probe trial after training. d&e, the swimming speed of the rats. Data are presented as mean ± SEM (n=12 in each group). #P<0.05, ##P<0.01 vs DEX. CTL: control; anta: antalarmin