Fig. 7From: Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in ratsThe effects of DEX treatment on CXCL5 level in the hippocampus in vivo and in vitro. a, DEX offspring of 2 days old were subcutaneously administered with CP154526 (30mg/kg/day) or antalarmin (20mg/kg/day) for a week. The protein level of CXCL5 in the hippocampus was determined by ELISA. Data are presented as mean ± SEM (n=8 in each group). ** P<0.01 vs control; # P<0.05, ## P<0.01 vs DEX. b&c, cultured hippocampal slices were treated with various concentration of DEX in the absence (b) and presence of CRHR1 antagonist (c) for 24h. Data are presented as mean ± SEM (n=4 cultures).*P<0.05 vs vehicle or indicated. CTL: control, anta: antalarmin, CP:CP154526Back to article page