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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Spatial learning and memory deficits induced by prenatal glucocorticoid exposure depend on hippocampal CRHR1 and CXCL5 signaling in rats

Fig. 7

The effects of DEX treatment on CXCL5 level in the hippocampus in vivo and in vitro. a, DEX offspring of 2 days old were subcutaneously administered with CP154526 (30mg/kg/day) or antalarmin (20mg/kg/day) for a week. The protein level of CXCL5 in the hippocampus was determined by ELISA. Data are presented as mean ± SEM (n=8 in each group). ** P<0.01 vs control; # P<0.05, ## P<0.01 vs DEX. b&c, cultured hippocampal slices were treated with various concentration of DEX in the absence (b) and presence of CRHR1 antagonist (c) for 24h. Data are presented as mean ± SEM (n=4 cultures).*P<0.05 vs vehicle or indicated. CTL: control, anta: antalarmin, CP:CP154526

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