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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy

Fig. 2

DPP4 participates in DAM phenotypic transformation in epileptic mice. a–c Gene expression in hippocampus from mice treated with kainic acid or kainic acid + sitagliptin (n = 6–7 per group). Selected markers: DAM: Itgax and Axl; homeostatic: Cx3cr1. d–f Representative western blotting images and statistical analysis of DPP4 and ITGAX in the hippocampus (n = 4). β-Actin was used as a loading control. g Representative overlay images of IBA1/ITGAX/DAPI staining in the hippocampus (IBA1, red; ITGAX, green; DAPI, blue). Scale bar = 25 μm. h The statistical analysis of ITGAX in IBA1+ microglia is shown on the left side. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094