Fig. 4

Histological observations of white matter in sham/BCAS-treated wild-type and Btg2^−/− mice. a, b Corpus callosum (a) and optic tract (b) subjected to Klüver–Barrera staining. Black arrowheads show vacuolation in myelin fibers. Scale bar = 20 μm. c, d Severity of white matter lesion (WML) in the corpus callosum (c) and optic tract (d). All mice were male. Data are adjusted means ± SEM. **p < 0.01 and ***p < 0.001, as determined by Tukey’s HSD test